Striker Calvin Zola and goalkeeper Steve Phillips will be included in Crewe's squad for the clash at Southend.
Zola, wanted by several of Crewe's rivals, failed to agree personal terms with Shrewsbury earlier in the week after both clubs had struck a deal and will make the trip after returning to Gresty Road.
Phillips, yet to appear this season following summer surgery on his shoulder, is expected to take his place on the bench with Rhys Taylor set to continue.
Teenage striker Nick Powell, a second-half substitute in last week's 3-3 home draw with Torquay, is unavailable as he is on international duty with England Under-17s.
Manager Dario Gradi has no new injury or suspension problems but defender Carl Martin (shin) remains a long-term absentee.