Colchester will be without left-back Marc Tierney for the trip to MK Dons.
Tierney sustained a dislocated shoulder during Tuesday night's 2-2 draw against Dagenham and could face a long spell on the sidelines.
Boss John Ward has moved for Bristol City defender Tom Williams on a month's loan as cover and he could start.
Captain Magnus Okuonghae needs a late check after suffering concussion against his former club in midweek, but the Us are confident he will be fit.
Fellow centre-half Pat Baldwin could return after missing the last two games with a foot injury but right-back Brian Wilson is still out with ankle trouble.
Midfielder John-Joe O'Toole and defender Morten Knudsen (both knee) remain long-term absentees.