Magnus Okuonghae has been ruled out of Colchester's FA Cup clash with non-league minnows Swindon Supermarine.
The defender is set to see a specialist after suffering a recurrence of the ankle injury which sidelined him for a while earlier this season.
Pat Baldwin stepped in alongside Paul Reid at centre-half against Brentford in midweek and could keep his place.
Skipper Kem Izzet will return to the midfield after sitting out Tuesday night's defeat through suspension.
On-loan Bristol City full-back Tommy Williams has missed three matches with a groin problem and will be checked over ahead of kick-off.
Steven Gillespie (thigh), Simon Hackney (back), John-Joe O'Toole and Morten Knudsen (both knee) are still on the casualty list.