The Chelsea boss will be anxiously hoping to pick up one of the easier opponents when the draw, made at UEFA's Nyon headquarters, is conducted.
He said: 'There are, of course, a lot of top teams also in those runners-up spot.''
One team with seven European titles [AC Milan] and, for sure, those will be the ones to try to avoid.'
Other teams Villas-Boas hopes to swerve includes the dangerous Napoli, who qualified at the expense of Manchester City, and Lyon, while Basle stand out as the dream draw - although they were responsible for Manchester United's exit.
Chelsea can also draw Marseille, Zenit St Petersburg and CSKA Moscow, and the latter two could present a challenge due to the freezing temperatures in Russia in February and March.
Villas-Boas, whose Porto side played CSKA and Spartak Moscow in the Europa League knockout stages last season, said: 'It happened to me last year in Porto twice and I have no problem with it.'
The synthetic pitch is also always difficult at CSKA but it's something that we think our players can handle.'
Zenit is a different story, a natural pitch. Of course, it's very, very cold.'
Villas-Boas added: 'Any team from now on is extremely difficult.
'What we wanted to try to do is win the trophy but it gets pretty difficult now.'
Arsenal join Chelsea in the seeded part of the draw after finishing top of their group, thus avoiding the prospect of drawing fellow pool winners such as Barcelona, Real Madrid, Bayern Munich and Inter Milan.
While Chelsea cannot play Bayer Leverkusen due to them being from the same group, Arsenal can, but will avoid Marseilles for the same reason.
Source: Daily_Mail
