The Blues visit the Potters looking to continue a recent resurgence in form that has given them a chance of successfully defending their league title.
Carlo Ancelotti's men lie nine points behind leaders Manchester United, but have a game in hand and have yet to go to Old Trafford in the league.
Huth the man: The former Chelsea defender is backing his team to turn over Carlo Ancelotti's side
But Tony Pulis' side are on an excellent run of their own. They are unbeaten in eight home games in all competitions and are through to the FA Cup semi-finals.
Huth believes Stoke are well-placed to put a major dent in Chelsea's title aspirations: 'The fact we are playing Chelsea does not give us fear. On our own turf we believe we can beat any team.' he said.
'We have done well at home recently and just as importantly we have looked good against the bigger teams.
'We have to stand strong, be brave and give it everything. We have quality players and this isn't a nice place for opposition teams to come to.'
Newcastle face Wolves in a crucial relegation clash at St James' Park. The Magpies lie 11th in the table, but only four points separate them from Mick McCarthy's men in 18th.
No chance: Ireland is once again unlikely to feature for Newcastle
Despite the importance of the game, Newcastle manager Alan Pardew has hinted he is unlikely to call on loan signing Stephen Ireland.
The 24-year-old, who is yet to kick a ball for the club since joining until the end of the season from Aston Villa in January, has an outside chance of making the squad for Saturday's game.
However, because he cannot play in the next game - at Villa - under the terms of his loan agreement, Pardew may leave him out until the following fixture, Manchester United's trip to Tyneside on April 19.
He said: 'Stephen Ireland is a tricky one because he probably has an outside chance of being involved this weekend.
'But he can't play at Villa, so it might be worth keeping him back and pencilling him in to be in and around for Manchester United.'
Bottom club Wigan will look to lift themselves off the foot of the table when they host top-four chasing Tottenham, while fellow strugglers Birmingham host high-flying Bolton.
There has been plenty of talk this week about whether England youngsters such as Jack Wilshere and Andy Carroll should be made available for the European Under-21 Championship in the summer.
But Wanderers boss Owen Coyle says he would be delighted for any of his squad to be involved.
He said: 'We will probably have Fabrice Muamba and Mark Davies, hopefully, involved plus Daniel Sturridge, who's here on loan, and ultimately I think you have to say it's a major championship and, if and when your players are involved, then there's tremendous pride. If my lads are involved, they will go with our blessings.' Didier Drogba lined up by Real Madrid in ?15m bid to keep Jose MourinhoFergie's got a point! Pulis backs United manager over Wembley semi-final furore All the latest Chelsea news, features and opinionAll the latest Stoke news, features and opinion
Explore more:People: Tony Pulis, Andy Carroll, Fabrice Muamba, Jack Wilshere, Robert Huth, Mick McCarthy, Owen Coyle, Carlo Ancelotti, Daniel Sturridge Places: Newcastle, Birmingham, United Kingdom