Javier Mascherano will also be back from suspension as the Anfield men look to overcome a 3-1 deficit.
Manager Rafael Benitez must decide whether to retain Daniel Agger in central defence, ahead of Martin Skrtel, after his goalscoring performance in the 4-0 Anfield rout of Blackburn on Saturday.
Chelsea captain John Terry is suspended as his team bid to hang onto their first-leg advantage.
Terry misses out after collecting a yellow card for his challenge on Reds goalkeeper Pepe Reina at Anfield.
Right-back Jose Bosingwa is expected to be sidelined because of hamstring trouble while Alex will replace Terry alongside Ricardo Carvalho in the centre of the defence.
Joe Cole and Paulo Ferreira are absent with knee ligament injuries.
Chelsea (from): Cech, Hilario, Belletti, Alex, Ivanovic, Carvalho, Mancienne, A Cole, Lampard, Ballack, Deco, Obi, Kalou, Essien, Malouda, Di Santo, Anelka, Quaresma, Stoch, Drogba
Liverpool (from): Reina, Arbeloa, Carragher, Agger, Hyypia, Skrtel, Aurelio, Dossena, Kuyt, Lucas, Mascherano, Gerrard, Alonso, Torres, Babel, Benayoun, Riera, Cavalieri, N'Gog.