The Slovak midfield star has long been linked with a move to England, with Chelsea thought to be leading the chase.
But Naples supremo De Laurentiis has moved to deny weekend reports that Chelsea have lodged an offer.
"I don't think Marek will be leaving Napoli," he told Sky Italia.
"He has a long contract with us and he is very well in Napoli.
"I won't just yield to any offer from Chelsea, we don't need their money."
A few days earlier his agent Juraj Venglos claimed that interest in Hamsik was mounting.
Venglos stated: "It is too early to talk about Marek's future, but indeed there is a strong interest in him."
PazziniMeanwhile, De Laurentiis confirmed his interest in taking Sampdoria striker Giampaolo Pazzini.
The 25-year-old is one of the form strikers in Serie A with six goals to his name, and now De Laurentiis admits he would like Pazzini.
A deal could involve midfielder Daniele Mannini - who moved to Samp in the summer, but is co-owned by Napoli.
"I am happy for Mannini. Last season he had a year that psychologically I wouldn't wish on anybody," De Laurentiis said.
"He has now rediscovered both mental and physical form and is doing very well. He's a good lad, very prepared, and he only needed to rediscover certainty and security.
"Samp are playing great. He is still 50 per cent owned by Napoli. If Marotta wants Mannini then I'll ask him for Pazzini."