Hargreaves has been out of action for nearly 18 months following major surgery on both knees, whilst O'Shea has not played a game since suffering complications in his recovery from a dead leg sustained in the Republic of Ireland's World Cup play-off defeat to France in November.
Back in business: O'Shea has missed much of the season
Wayne Rooney (ankle) is out, so £30.75million front-man Dimitar Berbatov is set to lead the United forward line.
Team (from): Van der Sar, Kuszczak, Foster, Neville, Rafael, De Laet, Ferdinand, Vidic, Evans, Evra, O'Shea, Park, Valencia, Carrick, Hargreaves, Scholes, Fletcher, Gibson, Obertan, Giggs, Nani, Berbatov, Macheda, Diouf.
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