The Seasiders have already recorded impressive home wins over Liverpool and Tottenham since the turn of the year, but with only two points currently separating them from the Barclays Premier League relegation zone, they could do with something similar against the Blues.
Following the 3-1 triumph against Spurs on February 22, Holloway's team were swiftly brought down to earth when they were hammered 4-0 at Wolves four days later - the same score by which they were defeated at Stamford Bridge back in September.
Get your teeth into that: Blackpool's DJ Campbell celebrates the second goal against Tottenham
Bouncing back with a win over the champions looks a tall order but Holloway is convinced his players have it in them to upset the odds once again.
'We've talked about what went wrong at their (Chelsea's) place, and spoken about Wolves very quickly and then moved on because it is important not to dwell on things,' Holloway said.
'You can only do something about the next one and that is something we have handled really well. What we need is a response and who's to say we can't do to Chelsea what we did to Tottenham.'
He added: 'If you look at the Tottenham game they had more possession, double the shots, but our finishing was lethal on the day.
'We need things to go our way and they will have to go better than they have ever to get three points off Chelsea.
'I believe we can get three points but we are going to have to be a tad fortunate and play the best we have played.'
Penalty king: Charlie Adam rams home the first goal against Spurs from the spot
Blackpool, promoted from the Championship via the play-offs last summer, have fared better in the top flight this term than many expected and with 10 games to go, remain very much in contention to beat the drop.
The Tangerines have been through plenty of highs and lows in their maiden Premier League campaign and Holloway has described the experience as a 'scary' rollercoaster ride - although he insists it is one he is still enjoying as much as ever.
'We've had almost a full season in the Premier League,' Holloway said. 'I look haggard and jaded but I'm loving every minute of it. It has been absolutely fantastic and I'm proud of how we've tried to acquit ourselves.
'Some days it has gone horribly wrong, but I've kept my dignity, kept smiling. We are nowhere near as low as we should be - we should be off the chart, halfway up in the Championship.
Key man: Blackpool will miss influential skipper Charlie Adam against Chelsea
'That's the truth, but we are riding this bubble of enthusiasm and on Monday we have one of the best teams in the land, in the country, in the world.'
Blackpool will be without their top-scorer DJ Campbell and captain Charlie Adam for this evening's contest.
Campbell begins a three-match suspension after he was sent off at Wolves, while Adam serves the second of his two-game ban for picking up 10 yellow cards this season.
Defender Stephen Crainey, who has not made a first-team appearance since January 22 due to an ankle injury, is in line to return against the Blues and midfielder Elliot Grandin, absent for the last two games with a hamstring problem, has an outside chance of being involved.
However, the match will come too soon for Gary Taylor-Fletcher (hamstring) and Matt Gilks (knee).
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