De Bruyne has long been linked with the Blues and revealed during the transfer window that the two clubs were in talks over his signature.
The 20-year-old ended up staying in Belgium, unlike team-mate Thibaut Courtois, who did move to Chelsea before being loaned out to Atletico Madrid.
Star asset: Mario Been (right) talks to Kevin De Bruyne at Stamford Bridge
De Bruyne will have a chance to impress Blues manager Andre Villas-Boas at close quarters during Wednesday night's Champions League Group E game at Stamford Bridge and the return match two weeks later.
Been, who succeeded Frank Vercauteren as Genk's head coach at the end of August, said: 'I know that Kevin is a really great player and that Chelsea already talked about him.
'Chelsea look and want to buy all the big talents so, for me, it wouldn't be a surprise if Kevin went to Chelsea. Everyone's got his price.'
Captain Daniel Tozser added of his team-mate: 'I think every game is a chance for him to show himself.
'Of course, he's a great talent. It's not surprising that Chelsea watched him.
'I hope personally he will show Chelsea tomorrow that they made a mistake in that he stayed with us.'
Preparation: Genk train ahead of their Champions League clash with Chelsea
Been added, jokingly: 'I hope he makes five goals.
'I think he will be sold then.'
Genk arrived at Stamford Bridge ravaged by injuries, particularly in defence.
'It's a pity we have this bad luck,' said midfielder Tozser, who insisted the visitors were confident of shocking their opponents.
'If not then we would not go out to the pitch,' he said.
'We will do everything to make it as difficult for them as possible.'
Genk have lost their last three matches and have failed to score in their opening two Champions League games against Valencia and Bayer Leverkusen.
Move: Thibaut Courtois joined Chelsea
Been admitted his side's recent form was a 'problem' but added: 'If I tell my players, 'We cannot achieve anything in this game', then it's better to stay home.
'A Dutchman is always positive and that is I what to give to my team.
'Losing against a team like Chelsea wouldn't be a great problem.
'First, we have to give 100 per cent and you never know what happens during 90 minutes.
'As a coach and as a player, these are things that you train for and play for.
'We know that we have to have a really good night to get a really good result against this Chelsea.
'They have a big selection with a lot of great players, so it's difficult for me to know who's playing tomorrow.'
Fernando Torres is likely to be unleashed on Genk, with the Spain striker currently serving a three-match domestic ban.
Been said: 'They can play (Nicolas) Anelka, they can play (Didier) Drogba, they can play Torres, they can play everybody.
'They have a lot of players who I will say can come to Genk and help us every week to get a better result.'
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