Chelsea striker Didier Drogba will miss Saturday's trip to Newcastle United with an ankle injury picked up during training.
Drogba reported back from international duty with the Ivory Coast earlier in the week fully fit, but picked up the injury during training on Friday.
"Drogba has a problem," revealed temporary coach Guus Hiddink.
"We did some exercise yesterday when he got injured. We did some shooting practice, he hit the ground with his toe and the reaction was in his ankle.
"He will not be in the squad for tomorrow. It's a little problem and he will hopefully be available for next Wednesday (Champions League clash with Liverpool."
Defender Jose Bosingwa will also miss the trip to the north-east with a hamstring problem picked up while playing for Portugal.
However, Nicolas Anelka is fit and available for selection after shaking off a toe problem which forced him to miss international duty with France.
Meanwhile, Hiddink claims he will still walk away from Stamford Bridge in the summer even if the Blues manage to win a Champions League and FA Cup double.
Hiddink is only under contract until the end of the season and has maintained his stance that he will leave to fulfil his commitments to the Russia national side since replacing Luiz Felipe Scolari in February.
"It would be a beautiful scenario to win both cups," he told the Evening Standard.
"In that case I will not walk away from Stamford Bridge in my mind, but I will have to literally walk away because I have my full-hearted obligations in Russia and that is not going to change if we win those two cups."