The Serbian has missed two games due to a calf strain but returned to training earlier this week and is expected to be fit, along with £30.75million record signing Dimitar Berbatov, who missed Tuesday's win over CSKA Moscow after taking a bang on his knee-cap.
Ready, set, go: Vidic (right) is back for Chelsea game
Rio Ferdinand (calf) is definitely out, along with Ji-sung Park (knee), while Gary Neville is suspended, so John O'Shea is set to return.
Team (from): Van der Sar, Kuszczak, Foster, O'Shea, Rafael, Brown, Vidic, Evans, Evra, Fabio, Valencia, Obertan, Anderson, Scholes, Carrick, Fletcher, Nani, Giggs, Rooney, Berbatov, Owen, Macheda.
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