Hilario will deputise for Petr Cech in Chelsea's goal against Man City, after the Czech Republic goalkeeper tore a calf muscle against Inter Milan in midweek.
Ashley Cole is a long-term absentee with a broken ankle and Yury Zhirkov has a calf injury.
Paulo Ferreira is back in contention after not being registered for the Champions League in midweek but Florent Malouda is expected to continue at left-back.
Jose Bosingwa, Michael Essien and Deco (all knee) all remain sidelined.
Team (from): Hilario, Ivanovic, Carvalho, Terry, Lampard, Mikel, Ballack, Malouda, Drogba, Kalou, Anelka, J Cole, Sturridge, Alex, Belletti, Ferreira, Bruma, Borini, Turnbull.
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Explore more:People:Deco, Jose Bosingwa, Ashley Cole, Michael Essien, Petr CechPlaces:Czech Republic