Chelsea are without midfielder Deco and right-back Jose Bosingwa (both hamstring) for the clash with Everton.
Playmaker Joe Cole and defender Paulo Ferreira are both out for the season with knee ligament injuries.
Everton striker Jo is available for the Merseysiders after being cup-tied for the FA Cup semi-final victory over Manchester United.
That game went to penalties and boss David Moyes could rest some of his players after their efforts.
Chelsea (from): Cech, Hilario, Belletti, Alex, Ivanovic, Carvalho, Mancienne, A Cole, Terry, Lampard, Ballack, Obi, Kalou, Essien, Malouda, Di Santo, Anelka, Quaresma, Stoch, Drogba.
Everton (from): Howard, Hibbert, Jagielka, Lescott, Baines, Osman,
Neville, Fellaini, Vaughan, Pienaar, Cahill, Saha, Rodwell, Nash, Yobo, Castillo, Jacobsen, Gosling, Jo.
This is a dress rehearsal for the all-blue 2009 FA Cup final.
Chelsea go into this match chasing silverware on three fronts. But trailing Manchester United by four points in the Premier League table having played one more game, a Champions League and FA Cup double has probably now become their more realistic goal, with the first leg of the semi-final of the former, away to Barcelona next Tuesday.
Everton are on course for a Europa League place, and will be sizing Chelsea up ahead of their end-of-season Wembley showpiece, which could result in a first FA Cup since 1995.
Victory for the Toffees would see them replacing Aston Villa in fifth place. Both clubs would then have five to play.
Everton have not prevailed in 21 league and cup matches against Chelsea, since a 2-1 home league victory on 25 November 2000, when Danny Cadamarteri and Kevin Campbell got their goals.
Chelsea have not lost their last 13 home Premier League games against Everton. They have won seven and drawn six since the Toffees' 0-1 win on 26 November 1994, when Paul Rideout scored the only goal of the game.