The Blues have every reason to be confident on the back of their fine league and domestic cup form.
Carlo Ancelotti has guided his side to four wins from five in the league with a draw at Blackburn Rovers slightly marring their fine run.
Three of these successes have came consecutively with resounding triumphs over Portsmouth (5-0) and Aston Villa (7-1), while their most recent joy was at title rivals Manchester United as they secured a pivotal 2-1 win.
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On Saturday, Chelsea secured their place in a third FA Cup Final in four seasons with a 3-0 victory over Aston Villa at Wembley.
The sharp-shooting Didier Drogba opened the scoring with Florent Malouda and Frank Lampard completing the rout and the feared threesome will be out to strike fear into the Trotters backline in the capital.
Bolton sit in 15th place in the league table and five points ahead of the drop zone and with three defeats out of their last three games, it will take a monumental effort to turn this around at the Bridge.
They have lost to Everton, Manchester United and Aston Villa recently without scoring and their toothless attack will be worrying Coyle.
A further win for Chelsea would place them in a strong position ahead of their challenging ask at Tottenham Hotspur at the weekend that could make their season.
Defensive quartet Ashley Cole, Ricardo Carvalho, Jose Bosingwa and Branislav Ivanovic will all miss the clash as will knee victim Michael Essien, but second-choice goalkeeper Hilario may make the bench.
The Trotters are likely to be missing Stuart Holden and Chris Basham while Gavin McCann, Sean Davis and Joey O'Brien are definitely out.
Last season at Stamford Bridge, Chelsea were handed an almighty fright as they secured a 4-3 victory.
Bolton had trailed 4-0 at once stage as Michael Ballack, a double from Drogba and a Lampard penalty put the hosts in total control.
However, the Lancashire side hit back through Andy O'Brien, Basham and Matt Taylor to set up frantic finale.