Chelsea will host Tottenham Hotspur in the FA Cup sixth round, while Championship outfit Plymouth Argyle's reward for reaching the last eight is a home tie with Watford.
Manchester City will travel to either Arsenal or Blackburn Rovers after seeing off Preston North End 3-1 at Deepdale.
The winners of the replay between Middlesbrough and West Bromwich Albion will play host to Manchester United or Reading.
The meeting of Argyle and Watford at Home Park is a repeat of the FA Cup semi-final of 1984, which was won 1-0 by the Hornets thanks to a George Reilly strike.
Middlesbrough or West Brom v Manchester United or Reading
Arsenal or Blackburn Rovers v Manchester City
Chelsea v Tottenham Hotspur
Plymouth Argyle v Watford
Ties to be played weekend of March 10 and 11.