Hull will begin life in their second season in the Barclays Premier League with a trip to Chelsea on August 15.
That is followed by successive home games against Tottenham and Bolton before rounding off the opening month with a trip to new-boys Wolves.
Trips to Liverpool and Arsenal are scheduled for September 26 and December 19 while champions Manchester United provide the opposition at the KC Stadium on Boxing Day.
The Tigers entertain Chelsea on January 9 and then travel to Tottenham on January 16 and Old Trafford 10 days later.
Arsenal are the visitors on March 13 before Phil Brown`s side bring the curtain down on their season with a home date against Liverpool on May 9.