Drogba has never been on the losing side against the Gunners, plundering 13 goals in 13 appearances to become their chief tormentor.
Wenger believes the Ivorian has the mentality to thrive when the pressure is on and fears his combination with midfielder Frank Lampard when the two sides meet on Monday night.
Chief tormentor: Didier Drogba has scored 13 goals in 13 games against Arsenal
'Drogba was always been very efficient against us. He is a big game player," said Wenger
'Recently when Chelsea were in trouble against Tottenham, who turned up? It was Drogba again.
'When you play against Chelsea he is the guy you need to keep quiet. The way he works in tandem with Frank Lampard is also important. Lampard always finds Drogba when he plays so we have to stop that.
'If you look at the statistics, defending against Drogba is one of the keys - if not the biggest key - of the game.'
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