Cesena have joined Palermo and Cagliari in hiring their third coach of the season after Daniele Arrigoni was fired and Mario Beretta hired in his place on Tuesday.
Cesena dropped to the foot of Serie A at the weekend following a 3-1 defeat at home to leaders AC Milan.
The coaching change was the 13th this season in Serie A.
Arrigoni was only hired in November to replace Marco Giampaolo, with whom Cesena began the campaign.
Beretta, 52, comes into the job with ample previous Serie A experience having coached Chievo, Parma and Siena.
Palermo were the first club to hire a third coach this season having fired Stefano Pioli before the league season began and then replaced Devis Mangia with Bortolo Mutti in December.
Cagliari sacked former Italy coach Roberto Donadoni in pre-season and then also dismissed his successor Massimo Ficcadenti, with Davide Ballardini currently in that role.
Donadoni re-emerged at Parma following Franco Colomba's demise and Pioli replaced Pierpaolo Bisoli at Bologna.
The highest profile sacking was at Inter Milan where Gian Piero Gasperini lasted only five official matches before Claudio Ranieri was brought in.
Genoa replaced Alberto Malesani with Pasquale Marino, Lecce swapped Eusebio Di Francesco for Serse Cosmi and Fiorentina waved goodbye to Sinisa Mihajlovic and welcomed Delio Rossi.
Perhaps the biggest surprise was at Novara where Attilio Tesser, who had guided the club to successive promotions, was sacked in favour of Emilio Mondonico.