Rangers travel to Celtic Park on Ladbrokes Premiership duty on Saturday for the first time in four years.
Here, we look at the talking points before the keenly-awaited Old Firm encounter.
FITNESS OF LEIGH GRIFFITHS
Celtic are sweating on the fitness of star man Griffiths. The Hoops striker, who has scored seven goals already this season, had to withdraw from the Scotland squad for the World Cup qualifier in Malta last Sunday with a hamstring complaint.
He trained at the start of the week at Lennoxtown but had to have a scan which will be assessed by boss Brendan Rodgers who, with a long season ahead, is wary of taking any chances.
Griffiths' absence would be an obvious blow to the Hoops and a boost to Rangers who are trailing Celtic at the top of the table by one point having played a game more.
DORUS DE VRIES v WES FODERINGHAM
Rodgers replaced goalkeeper Craig Gordon with Dorus de Vries almost immediately after signing the Dutchman and he will be one of several debutants from both sides in this fixture.
Rangers keeper Foderingham played in the William Hill Scottish Cup semi-final against the champions last season but this will be his first time between the sticks at Celtic Park. He is likely to be the busier keeper but how both players react to the atmosphere will have a bearing on the outcome.
SCOTT BROWN v JOEY BARTON
The most tantalising sub-plot to what is sure to be a fraught and frantic lunchtime encounter is the match-up in midfield of Celtic captain Scott Brown and Rangers' Joey Barton.
Soon after signing for the Ibrox club in the summer, the Englishman raised eyebrows when he was so dismissive of Brown, claiming that he was "nowhere near his level".
Barton's start to his Ibrox career has been indifferent and he is under pressure to walk the walk at Parkhead. All eyes will be on the first challenge.
TACTICS
Rangers boss Mark Warburton worked briefly with Rodgers at Watford and the former has become used to seeing his side have the bulk of possession. Rodgers has found that too, in his short time in Scottish football. The former Swansea and Liverpool boss is not slow to change systems and personnel and more than once during a game while "Plan B is to do plan A better" has been Warburton's mantra since he arrived in Govan. It will be intriguing to see how both men set their teams up and what they change during the match.
FANS
It is the first league meeting between the two clubs in four years. Celtic Park will be filled to its 60,000 capacity, with around 7,500 wearing red, white and blue. Inside the stadium is normally the safest place to be on an Old Firm day but with tensions running higher than usual, both sets of supporters will be under scrutiny. And police have warned them to that effect.
Source: PA-WIRE
