Port Vale boss Micky Adams is set to shuffle his pack and give some of his fringe players starts.
On-loan striker Jemal Johnson will figure after parent club MK Dons gave Vale permission to play him.
Port Vale defender Gareth Owen told BBC Radio Stoke: "We know where we went wrong (against Oxford) and we're going out to put that right.
"It's a game of football and you want to win every game of football, even if the manager makes changes.
"He's making changes because the lads on the touchline deserve a chance and it's up to the lads who get that shirt to put in a performance, then they could be in charge of it on Saturday as well."