Cardiff need three points to consolidate their play-off chances, while a win for Swansea would see them climb to within two points of their rivals.
And the Swans defender believes the stakes are even higher for Dave Jones' men to win what could transpire to be the last ever derby at Ninian Park.
"The pressure is definitely all on Cardiff, as they are at home and there is nothing worse than losing a derby game on your own patch," Monk told Wales Online.
"As much as it's good to have the fans right behind you, the added pressure means you know you can't afford to lose - especially with such huge bragging rights on offer.
"They certainly won't want to be the team that lost the last derby at Ninian Park either. It's all added pressure which is good for us."