Cardiff manager Dave Jones must decide whether to include unsettled striker Ross McCormack, who is wanted by Hull.Former Norwich goalkeeper David Marshall will make his competitive debut for the home side.
Scunthorpe have been boosted by the news that centre-backs Rob Jones (groin) and David Mirfin (ankle) have both been passed fit.
Gary Hooper has recovered from a slight back strain, but Kenny Milne is not yet ready to return after a knee injury.
Jones has kept his job but his preparations for the opening game have been marred by uncertainty over the futures of Ross McCormack and Joe Ledley, not to mention the sale of defender Roger Johnson to Birmingham.
Promoted Scunthorpe are aiming to cause a surprise this season, so a chance to ruin Cardiff's big day is a good test of their credentials.
Last season's 30-goal striker Gary Hooper will relish the chance to unsettle the home side. He struggled to make an impact at this level with Southend but may pose a big threat this time around.
• Scunthorpe have drawn five of their last six league games at Cardiff.
• The Iron have not beaten the Bluebirds since October 1995, when they won 1-0.
• Manager Dave Jones is now the longest-serving boss in the Championship.
• If forward Jay Bothroyd is selected, he will make his 200th English league appearance.
• The Iron have failed to win any of their last four opening league fixtures, and only won one of the last eight.
• David Mirfin could make his 200th club career start.
MOST RECENT MEETING
Scunthorpe 3-2 Cardiff 19 April 2008
Scunthorpe scorers: Hayes 53, 90 (pen), Hurst 56.
Cardiff scorers: Hasselbaink 45, Ledley 59.