Burton Albion claimed the only upset on FA Cup second-round day as a fifth-minute goal from Calvin Zola proved enough to give the npower League Two outfit a 1-0 away to League One strugglers Crewe.
Fellow League Two side Port Vale had looked set to join them in the headlines with Tom Pope's 33rd-minute strike putting Micky Adams' men within sight of a famous win over Sheffield United at Bramall Lane. But the Blades dealt a double blow to Vale's dreams of an upset with a late Shaun Miller brace to give his side a dramatic 2-1 win.
Blue Square Premier Luton are the first non-league side guaranteed a place in the third-round draw after goals from Andre Gray and Alex Lawless gave the Hatters a 2-1 victory over Conference South Dorchester at Kenilworth Road.
Harrogate Town and Hastings United will join Luton in the hat after playing out a 1-1 draw at Wetherby Road. Tom Platt's header put Harrogate ahead after 41 minutes before Jamie Crellin equalised for the Ryman Premier visitors.
And Blue Square Premier pair Lincoln and Mansfield must do it all again in their bid to join the big guns after a 3-3 draw at Sincil Bank, while Chelmsford's Cup dream came to an end in a 3-0 defeat at Crawley.
Liam Cooper gave League Two Chesterfield a shock lead against League One leaders Tranmere at Prenton Park, but goals from Cole Stockton and Adam McGurk rescued a 2-1 win for Rovers.
League Two leaders Gillingham were not so fortunate, falling 2-0 at League One Preston, while Oxford claimed a second chance against Accrington Stanley after a dramatic 3-3 draw.
Gary McSheffrey's 38th minute penalty paved the way for Coventry's 2-1 win over League Two Morecambe at the Ricoh Arena, while a late double from Matt Derbyshire ensured Oldham's progression with a 3-1 victory over Doncaster.
Danny Hylton scored twice as struggling Aldershot claimed a surprise 3-2 win at League Two rivals Fleetwood, and Bournemouth's long trip to Carlisle proved worthwhile as Wes Fogden's early goal set up a 3-1 away win.
League Two Rotherham earned a second crack at Notts County after holding the League One side to a 1-1 home draw, while Bury face a midweek replay at Southend after they were deadlocked by the same score at Gigg Lane.