Burnley defenders Tyrone Mears and Stephen Jordan are both suspended, while centre-back Steven Caldwell is out for a month with a groin problem.
The Clarets are hoping on-loan David Nugent will be allowed to feature.
MK Dons manager Paul Ince told BBC Three Counties Radio:
"I've been involved in lots of games, and if the Premier League team don't come and play, and aren't on top form then there is no reason why we can't win the game.
"If you can't enjoy playing against top level opposition, then you shouldn't be involved in football."
BIG-MATCH FACTS The tie in context
• This is one of five third round ties pitting a League One club against a top-flight side.
• Milton Keynes Dons are one of 12 third tier clubs competing in this round.
Gulf in class
• Burnley are superior to the Dons by some 38 places.
Head-to-head FA Cup records and best performances
• This is the first meeting of these clubs since Milton Keynes metamorphosed from Wimbledon.
The clubs MILTON KEYNES DONS
• The Dons have won three of the last five, but lost two of the most recent three games, without scoring in either.
FA Cup form
• Paul Ince' side are vying for a first appearance in the fourth round since their change of identity.
• Drawn at home for the fourth round running.
• Not won in nine (D5, L4).
• The 2-0 home triumph over Hull on 31 October is their only victory in 12.
• Lost their last four away matches, and not scored in three (all Premier League games).
• Gained only one victory on the road this season, against Hartlepool in the second round of the Carling Cup on 25 August.
FA Cup form
• The Clarets accompanied a run to the semi-finals of the League Cup, with a fifth round appearance in the FA Cup last season.
• In the last six years, they have either progressed to the last 16 (three times), or been knocked out in the third round.
Replay date Tuesday, 12 January (Kick off: 1945)
Match officials Referee: Tony Bates (Staffordshire)
Assistant referees: Michael Murphy & Ian Smedley
Fourth official: Steve Rushton