In doing so, he made Burnley the first team from a lower division to beat Arsenal during Arsene Wenger's 12-year reign. McDonald has not found the net in 13 matches since but will accept drawing another blank in Sunday's encounter at the Emirates Stadium if the side can pull off another shock.
In addition to Arsenal, Owen Coyle's side have already beaten Premier League clubs Chelsea, Fulham, West Brom and Tottenham in cup ties this season. But taking on the Gunners in north London with a quarter-final tie at home to Hull awaiting the winners is probably their toughest task.
"This is a little bit different; this is the biggest one," said the former Dundee midfielder. "It's the FA Cup, and going to the Emirates is a big experience for the players. But you have to treat every game as it comes. There is no difference, no change.
"For me it is the same mentality against Arsenal as it was against Blackpool (a 1-0 win in the Championship) on Wednesday. I'd be happy to take anything from there - I'd be happy to get a replay. I don't think they will be bothered too much [by his previous two goals against them]. But if we were to upset them again it would be brilliant. We'll just have to wait and see. If we give it our all we have a chance, and that is all the fans and the manager ask for on the day."