McCann is to see a specialist next week about the niggling knee injury problem that has curtailed his pre-season.
McCann, who missed a large chunk of last season with two knee injuries, is currently undergoing treatment for a knock sustained during the Clarets' tour to Singapore.
He has been out of action since and boss Brian Laws is keen to get a second opinion on the problem.
McCann's absence aside, Laws has four new signings at his disposal for the Championship opener at Turf Moor in Chris Iwelumo, Ross Wallace, Dean Marney and Lee Grant.
Laws said: "Everyone apart from Chris McCann is fit and available and vying for a place in the team."