Midfielder Lescott and full-back Hughes were struggling with knocks earlier in the week but will be available to face the Glovers.
Defender Danny Coles returns after missing the defeat at Southend last weekend ago through illness.
Manager Paul Trollope must decide whether Steve Elliott will keep his place in the centre of defence, after the former Derby man made his first League One start of the season at Roots Hall.
Elliott will compete with Coles and Byron Anthony for a starting berth, while Dominic Blizzard and Andy Williams are pushing for a place in Trollope's side.
Ben Hunt will definitely not feature due to a calf injury.