A goal from Craig Mackail-Smith on the stroke of half-time was enough to secure Brighton's second win of the fledgling npower Championship season as they beat Portsmouth 1-0 at Fratton Park.
Gus Poyet's side celebrated a return to the second tier with victory over Doncaster last weekend and the Seagulls continued their good start after Mackail-Smith's winner, although only a last-minute penalty miss from Liam Lawrence kept them in front.
Fellow Championship newcomers Southampton also continued their 100% start to the new league campaign with a 1-0 win at Barnsley. Veteran striker David Connolly's close-range header on the half-hour mark was enough to secure victory for Nigel Adkins' men, who survived a late Barnsley rally after substitute Richard Chaplow was sent off.
Leeds finished with nine men as they went down 1-0 at home to Middlesbrough, who themselves had Tony McMahon sent off just before half-time. Max Gradel was the first Leeds player to see red by McMahon quickly followed him down the tunnel and the game was evenly balanced until Jonny Howson was also dismissed on the hour.
A Marvin Emnes goal midway through the second half was enough to give Boro their first league win of the season and end a miserable day for Leeds which began with a pre-match protest by a section of the home supporters against chairman Ken Bates.
Sam Allardyce celebrated his first win as manager of West Ham after new Hammers captain Kevin Nolan scored a fifth-minute goal that proved to be enough for a 1-0 win at Doncaster.
Free-spending Leicester were brought back down to earth as last season's beaten play-off finalists Reading picked up a 2-0 win against Sven-Goran Eriksson's side at the King Power Stadium. Noel Hunt scored the opener after 64 minutes, before substitute Hal Robson-Kanu wrapped up all three points in the final minute.
The unconvincing start to Steve McLaren's tenure at Nottingham Forest continued as they were beaten 2-0 at Millwall. Darius Henderson scored his first Millwall goal on his home debut in the opening stages and, as the Reds struggled to find a way through, Liam Trotter made sure of the win on the counter-attack with 13 minutes to play.
A 73rd minute goal from Keith Fahey earned Birmingham a 1-0 win against Midlands rivals Coventry at St Andrews in a largely even contest. Matt Fryatt struck the only goal of the game as Hull won 1-0 at Ipswich while Derby striker Steve Davies scored his second winning goal in a week as his solitary strike gave the Rams victory at Watford.
Crystal Palace picked up an impressive 2-0 win over Burnley with Jonathan Parr opening the scoring early on before a second-half Owen Garvan penalty secured the points for Dougie Freedman's side, before Clarets substitute Marvin Bartley was dismissed at the end.