Brighton captain Gordon Greer has been passed fit for the trip to Southampton.
The defender had to be substituted during Saturday's 2-2 draw against Bristol Rovers through illness but he will make the trip along the south coast.
The Seagulls will be without Greer's fellow centre-half Tommy Elphick, who is suspended after picking up his fifth booking of the season at the weekend.
Liam Bridcutt serves the final game of his three-match ban, Matt Sparrow is still missing with a groin injury and Alan Navarro continues his recovery from cruciate ligament damage.
Assistant manager Mauricio Taricco could be added to the bench after serving a one-match ban against Rovers following his red card in the FA Cup replay at Woking.