Carlisle have no new injury or suspension worries for their second Johnstone's Paint Trophy final in as many years.
Francois Zoko is expected to partner Ben Marshall up front.
The two sides travel to Wembley with three points separating them in the League One table, Brentford lying ninth and Carlisle 11th before Saturday's matches.
The Cumbrians, winners in 1997, are appearing in a record sixth final, the most recent of which was last year's 4-1 defeat by Southampton.
Brentford are looking for their first success after being beaten in the 1985 and 2001 finals.
But it is the Bees who arrive at the final in better form, having won their last three games, including a 2-1 victory over Carlisle at Griffin Park.
Indeed, the London club have lost only three times since parting company with manager Andy Scott on 3 February.
Nicky Forster was placed in temporary charge, seeing his side win through to Wembley in his second match at the helm with a 2-1 area final second leg win over Exeter, and the former Brighton striker was given the job until the end of the season at the beginning of March.
In contrast to the Bees, Carlisle, who held on to beat Huddersfield 4-3 on aggregate in their area final, have won only one of their last five games.
Brentford manager Nicky Forster told BBC London: "It's been a bit of a whirlwind but we are where we are and I'm looking forward to the challenge.
"The work had been done before me, so whoever took over was in a very privileged position and I don't take that for granted.
"Training has been light, vibrant and bright. The competition for places has given me a good headache.
"Carlisle are a very good team and we've got to give them a lot of respect. The fact that we beat them in the league will have no bearing on the game."
Carlisle midfielder James Berrett told BBC Radio Cumbria: "For the club to get to the final again is a massive achievement and we're all looking forward to it.
"There hasn't been much talk of this game, we've just been concentrating on the games beforehand. Now we'll get to work on what they're going to do and what we're going to do.
"Brentford are a similar club to us, so it will be down to who deals with the circumstances on the day."