Ricardo Teixeira has stood down as head of the Brazilian Football Federation and the 2014 World Cup organising committee due to concerns about his health.
Teixiera had been in charge of Brazilian football for 23 years but recently came under pressure to resign over allegations of corruption.
He announced over the weekend he would be taking a leave of absence due to his health and confirmed on Monday that his departure was permanent.
A statement read: "I leave the presidency of the CBF (national federation) permanently with the sense of mission accomplished.
"It's not easy to preside passion. Football in our country is associated with two things: talent and disorganisation.
"When we win, talent is praised. When we lose, it's about disorganisation.
"I did what was within my reach, sacrificing my health. I was criticised in the losses and undervalued in the victories."