Brazil forward Robinho will miss Tuesday's first knockout round clash with Ghana because of a troublesome thigh injury.
The 22-year-old Real Madrid star replaced Adriano for last Thursday's Group F match against Japan and played a key role in the 4-1 victory.
However, a statement from the Brazilian Football Confederation read: "Robinho is ruled out of the match and will continue his physiotherapy."
It is hoped Robinho will be fit enough to play in the quarter-finals - if Brazil beat Ghana.
Adriano is expected to return to the side for the game against the Black Stars to partner Ronaldo in attack.