Megson is relishing the date at the Britannia Stadium, insisting the game has a lot of merit and is worthy of respect.
He said: "It will be a classic in terms of support, atmosphere - and 22 honest players giving it a right, good go.
"We will all be trying to get the points. If you are prepared for a good, old-fashioned British game it will be something like that."
Bolton are aiming for their fourth win in five games, after defeating Newcastle at the weekend.
A place in the UEFA Cup could be open to the club that finishes seventh in the table, following Manchester United's Carling Cup victory.
Bolton are within touching distance after a good run of form, but Megson is refusing to contemplate the prospect of European football for the second time in three seasons.
"That is not something we are looking at, " he said.
"Purely and simply we want to get three points against Stoke, then move on to the next game.
"I have not set the players any targets. We just want to do the best we can."
Megson had a spell as Stoke manager and coach - alongside current boss Tony Pulis - and expects a stiff test.
The home side go into the match of the back of taking a point against Aston Villa, and Megson said: "That will feel like a win. It will be a huge boost for them.
"I still feel Stoke will stay up. The fact they are in the Premier League is down to Tony. He knows his stuff.
"It has always been a tough place to go. Not only is the team up for it, but so are the crowd.
"They are loud and very passionate, and that can pile the pressure on. I think they've had five penalties at home."
Stoke v Bolton Correct Score: Draw 0-0 15/2