Carlisle said: "The Burnley fans feel a bit bitter about the way the gaffer left and the atmosphere may be a bit acrimonious so it should be a lively one!
"It will be full-blooded and the lads will be fighting tooth and nail to get the points."
The defender insists however that there is no bad feeling towards Coyle from the Burnley players, who will offer a friendly hand-shake to their old manager.
"You find in football you generally cross paths with people at some point in the future so you make sure you are professional and courteous, and all smiles," added Carlisle.
"Football is like Hollywood - never stand on anyone on the way up because you're going to have to wave at them on the way back down."
The miserable away record has become something of a curse for Burnley's players, who desperately need to end that run.
Carlisle added: "It would be ironic if that away win was to come against the former manager, but the most important thing for the players is to break this duck as soon as possible.
"We have to get this monkey off our back - it's grown from a chimp, to an orangutan to a mountain gorilla - but we must make sure it does not make us play with fear."
Strikers David Nugent - whose loan deal expires at midnight - and Steven Fletcher should both be available on Tuesday night after missing the FA Cup defeat by Reading but club captain Steven Caldwell is still missing.
Burnley manager Brian Laws said the club are still trying to persuade Portsmouth to let Nugent extend his loan deal to the end of the season.
Portsmouth want to sell the 24-year-old to bring in some money to the cash-strapped club but the player is keen to remain on loan at Turf Moor.
Laws said: "The chairman has been in constant contact to get it concluded but they are delaying in because they want to sell the player - I think they want to sell a few players.
"David himself holds the aces, however, and he wants to be at Burnley on loan until the end of the season and then reassess his position in the summer."
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