The Seasiders dumped Wigan out of the Carling Cup on Wednesday with a thumping 4-1 success and Charlie Adam, Ben Burgess and Gary Taylor-Fletcher - who all netted against the Latics - were on target again.
Adam fired home from the penalty spot in the 13th minute and Burgess claimed a far-post header shortly before the hour mark before Taylor-Fletcher added a third in the 70th minute.
The result got Holloway's men up and running after four successive draws in the Championship and left shot-shy Coventry with just one point from their last three outings.
Yet Chris Coleman's men almost led inside the second minute when
Aron Gunnarsson crossed dangerously and on-loan Chelsea youngster Jack Cork drove a left-foot shot wide from 12 yards.
Moments later Adam fired a 20-yard free-kick wide of Keiren Westwood's left-hand post but in the sixth minute the hosts went desperately close as Taylor-Fletcher hit the crossbar.
Veteran forward Brett Ormerod flighted in a dangerous delivery and Taylor-Fletcher rose highest to head the ball against the crossbar.
The respite was to prove only temporary for the Sky Blues, however, as Sammy Clingan fouled Burgess and referee Nigel Miller pointed to the penalty spot.
Adam dispatched the ball emphatically into the bottom corner with a fine left-foot strike and immediately went in search of his second goal.
He fired in a fierce shot from 12 yards but Martin Cranie bravely blocked the ball to deny the former Rangers midfielder.
In the 20th minute, Burgess tried his luck from distance but Westwood was more than equal to his 25-yard strike.
Coventry full-back Stephen Wright then had a shot blocked by Jason Euell and Burgess volleyed over the crossbar as chances continued to come and go.
Sky Blues defender Patrick van Aanholt drilled a thunderous effort goalwards in the 34th minute which Paul Rachubka caught comfortably.
Keith Southern and Taylor-Fletcher both went close before the break and shortly after the restart Adam hit a right-foot shot over from 35 yards.
In the 59th minute, Blackpool grabbed their second with a fine strike from Burgess.
Euell played in Ormerod down the left flank and his superb cross was nodded in at the far post by Burgess.
It was the former Hull striker's third goal of the season but he was forced off through injury soon after and replaced by on-loan Arsenal youngster Jay Emmanuel-Thomas.
Coventry refused to surrender and almost grabbed a lifeline in the 63rd minute when Freddy Eastwood drew a brilliant save from Rachubka with a fine 18-yard strike.
But Blackpool added a third with 19 minutes remaining when Taylor-Fletcher buried a right-foot shot from six yards after connecting with another fine cross from Ormerod.