The 24-year-old could be out for up to six weeks after suffering a recurrence of an old knee ligament injury. His absence could see Wales international Neil Eardley, who was substituted at half-time at Chelsea last week, come in at right-back.
Manager Ian Holloway has no other new injury concerns but changes are possible following the 4-0 hammering at Stamford Bridge.
Billy Clarke (knee) is a long-term absentee.
Holloway is happy to be back at home after learning some harsh lessons on his travels. Holloway's side play only their second game at Bloomfield Road since winning promotion.
Building work has meant four of the Tangerines' first five games have been on the road and two of them have proved rude awakenings - a 6-0 hammering at Arsenal and a 4-0 thrashing by Chelsea.
"Whatever we'd have done we'd still be out there now languishing against a team that are light years ahead of us," said Holloway of the Stamford Bridge drubbing.
"Whatever I did, whatever I tried they were better than us.
"At half-time it was already done and dusted - they were that good, they scored a goal every 10 minutes. But let's move on. We've got Blackburn at home.
"It'll be nice to have a home game. We have only had one home game and that seems a lifetime ago. When I walked across the grass I thought I was on someone else's pitch. I want to try to score some goals. If we can do that, we might be a handful."
Blackburn will be without the quartet of David Dunn, Keith Andrews, Vince Grella and Jason Roberts. Grella sustained a hamstring problem in last weekend's draw against Fulham and did not feature in the Carling Cup defeat at Aston Villa in midweek.
Dunn has not played since the end of August while Andrews and Roberts have yet to feature this season because of injury.
Manager Sam Allardyce will make changes to the side he named for the Carling Cup, with Paul Robinson returning in goal.
Holloway's success with the Seasiders deserves to be ranked alongside any of the achievements of Sir Alex Ferguson or Jose Mourinho, according to Allardyce.
Holloway, working on a shoestring budget, won promotion to the Barclays Premier League via the play-offs in his first year in charge.
Having taken Leicester down to League One in his only season in charge at the Walkers Stadium and then spent 12 months out of work it was a remarkable turnaround in fortunes for the Bristolian.
Allardyce, who takes his side to face the club he managed in the mid-1990s, believes Holloway's work has not been appreciated as much as it should.
"He has been a good manager for many years," he said.
"This is a major achievement and there are not many managers who have done what he has done and he should be very proud of his successes.
"When you look at what resources they have we don't give them the plaudits they deserve because they are a small, unfashionable club. But in terms of resources and finance it lies alongside anything Alex Ferguson or Jose Mourinho has done, in reality."
Source: DSG
