Spurs could have an entire team out injured and only one fit striker for the visit of Rovers.
Eight players are definitely sidelined, with a further three rated doubtful, including Tom Huddlestone (ankle), Roman Pavlyuchenko (back) and David Bentley (calf).
Robbie Keane (ankle) and Aaron Lennon (hamstring) remain sidelined, and Giovani dos Santos (groin) is also out, joining captain Ledley King (groin), Jermain Defoe, Michael Dawson (both ligament damage), Jamie O'Hara (back) and Jonathan Woodgate (groin) in the treatment room.
Rovers boss Sam Allardyce has no fresh injury concerns.
Striker Jason Roberts is pushing for a place in the starting line-up having come off the bench to score the winner in Rovers' last two games.
Benjani Mwaruwari, Martin Olsson, Steven Nzonzi, Keith Andrews and Vince Grella are all yet to regain full fitness.
Spurs (from): Gomes, Cudicini, Hutton, Corluka, Bale, Gallas, Bassong, Kaboul, Jenas, Sandro, Assou-Ekotto, Huddlestone, Palacios, Kranjcar, Bentley, Modric, Crouch, Pavlyuchenko, Pletikosa.
Blackburn (from): Robinson, Nelsen, Samba, Salgado, Jones, Givet, Pedersen, Dunn, Emerton, EH Diouf, MB Diouf, Kalinic, Roberts, Chimbonda, Hoilett, Linganzi, Goulon, Bunn, Hanley.