Chelsea and Tottenham both maintained their 100 per cent starts to the new season on an afternoon when Liverpool came from behind to beat Bolton.
Champions Manchester United also hit back in the evening game to defeat Arsenal 2-1 at Old Trafford.
The Gunners controlled much of the first half and took the lead through an excellent long-range strike from Andrey Arshavin five minutes before the interval.
United improved in the second period and Wayne Rooney equalised from the penalty spot in the 59th minute after being brought down by Manuel Almunia.
Abou Diaby then headed a Ryan Giggs free-kick into his own net five minutes later to put United ahead, while the game ended with Arsenal boss Arsene Wenger being sent off.
Chelsea were highly impressive as they chalked up a fourth successive league win via a 3-0 defeat of Burnley.
The Clarets will rue Martin Paterson's profligacy in front of goal with the scoreline blank, as once Nicolas Anelka broke the deadlock on the stroke of half-time there was no way back.
Michael Ballack stooped to double Chelsea's lead after the break before Ashley Cole's stunning angled drive capped another imperious display from Carlo Ancelotti's side.
Tottenham left it late at White Hart Lane as Aaron Lennon's last minute strike against Birmingham City secured a 2-1 victory.
Worryingly for Harry Redknapp, Ledley King and Luka Modric hobbled off injured before the latter's replacement, Peter Crouch, scored his first Spurs goal with a looping second-half header.
Lee Bowyer restored parity via the scruffiest of efforts as Christian Benitez appeared to push Alan Hutton in the build-up to the goal, much to the ire of Redknapp, and the delight of a travelling Blues faithful.
It was, though, Spurs who had the last laugh as Lennon's impressive drive won it at the death.
Rafa Benitez has experienced better weeks in his football career and he'll be thankful for Steven Gerrard after his captain scored a thumping winner as Liverpool won 3-2 at ten-man Bolton.
Following Monday night's defeat to Aston Villa, things got a whole lot worse for Liverpool just past the half-hour mark when Bolton striker Kevin Davies stabbed home after a scramble in the box.
Davies' opener had come against the run of play so it came as little surprise when the in-form Glen Johnson restored parity before half-time when he cut inside on the edge of Bolton's box, before firing a daisy cutter beyond Jussi Jaaskelainen.
It was, though, a frailty at the heart of Liverpool's defence that was exposed again after half-time as Davies' flick header from a set-piece fell invitingly for Tamir Cohen to ram home.
Sean Davis saw red for two bookable offences before Gerrard struck the bar and Fernando Torres levelled matters with a neat finish. The scene was set for Gerrard to emerge as a hero and he did just that with seven minutes remaining, via a searing drive from range.
Hull City and Wolves both went for three points in a bright game at Molineux but had to settle for one apiece after a 1-1 draw.
Stephen Hunt continued an encouraging start to his Hull career as his powerful run and cross from the left was headed in by Geovanni past Wolves goalkeeper Wayne Hennessey.
Wolves struck back early in the second half when a free-kick from deep fell to Richard Stearman, who finished with aplomb for a centre-half.
Dave Kitson followed up his first ever Stoke goal in midweek, in the Carling Cup, with a debut league strike as his first-half effort was enough to give the Potters a 1-0 win at home to Sunderland following a scramble in the box.
Blackburn's game with West Ham at Ewood Park ended in a disappointing stalemate as neither club did enough to take the spoils.