The pair were both rested against Rangers in midweek, but despite keeping a clean sheet at Ibrox, Jonny Evans and Chris Smalling will stand down.
Return of the big guns: Rio Ferdinand (left) and Nemanja Vidic are expected to reclaim their starting spots in defence
Patrice Evra will also play but Darren Fletcher (ankle) is definitely out and Paul Scholes (groin) is doubtful.
Team (from): Van der Sar, Amos, Rafael, O'Shea, Brown, Ferdinand, Vidic, Evans, Smalling, Evra, Fabio, Nani, Park, Carrick, Scholes, Anderson, Obertan, Giggs, Rooney, Berbatov, Hernandez, Macheda, Bebe.
CLICK HERE FOR THE WEEKEND TEAM NEWS IN THE BARCLAYS PREMIER LEAGUE Explore more:People: Paul Scholes, Darren Fletcher, Bebe, Rio Ferdinand, Patrice Evra, Nemanja Vidic, Nani