His absence causes problems for manager Rafa Benitez as fellow centre-back Sotirios Kyrgiakos serves the final game of a three-match suspension.
Unlucky break: Skrtel had to leave the field on a stretcher in Romania
Jamie Carragher is likely to revert to his usual role in the centre, meaning Philipp Degen or youngster Martin Kelly could come in at right-back as, although Glen Johnson is close to full fitness after a knee problem, he is not in contention yet.
Midfielder Maxi Rodriguez returns to the squad having been ineligible for the trip to Romania.
Provisional squad: Reina, Degen, Agger, Carragher, Insua, Gerrard, Lucas, Aquilani, Benayoun, Riera, Rodriguez, Ngog, Kuyt, Torres, Cavalieri, Pacheco, Spearing, Darby, Babel, Aurelio, Kelly.
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