The two sides played out a hugely entertaining 2-2 draw at Ewood Park ten days ago, with Rovers only claiming a replay thanks to an injury-time equaliser from Chris Samba.
Despite being embroiled in the Premier League relegation battle, Rovers boss Sam Allardyce is determined to secure a place in the quarter-finals - where the winners will host Chelsea.
Likewise, Coventry boss Chris Coleman is going all out to clinch a spot in the last eight.
The Sky Blues are safe in mid-table and Coleman knows they have nothing to lose from going all out to beat Rovers.
Team newsColeman is set to make changes with on-loan Sunderland winger Jordan Henderson poised for a recall to the starting line-up after an excellent cameo performance at the weekend after coming on as a substitute against Birmingham.
Leon McKenzie is sidelined with an Achilles injury which rules him out of contention.
James McPake is ready to return to the side in place of Scott Dann - who is suspended.
Allardyce has doubts over Vince Grella and David Dunn for the trip to the Ricoh Arena and he may not risk either player.
El-Hadji Diouf is cup-tied, but Samba is ready to return after serving a suspension at the weekend.
Danny Simpson is also available again and is likely to come in at right-back with Martin Olsson in line to start at left-back.