Chelsea travel to Blackburn after back-to-back Barclays Premier League defeats and the Portuguese is set to make changes to his back four at Ewood Park.
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Jose Bosingwa - who has been highly criticised in recent weeks - could be dropped in move that would see Branislav Ivanovic shifted out to right-back.
John Terry will return to the heart of Blues defence after being rested for the midweek 1-1 draw in Genk and will be partnered by either David Luiz or Alex on Saturday.
Chelsea have not kept a league clean-sheet since the opening day draw against Stoke, something that has not been lost on Villas-Boas.
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'Defending is about collective organisation,' said Villas-Boas.
'If there are collective mistakes, we have addressed them. We went a step up in our organisation against Genk. We have to continue to transfer that into our games.'
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