Blackpool are without defender Alex Baptiste as they face Rovers in only their second home Premier League match.
The 24-year-old could be out for up to six weeks after suffering a recurrence of an old knee ligament injury.
His absence could see Wales international Neil Eardley, who was substituted at half-time at Chelsea last week, come in at right-back.
Manager Ian Holloway has no other new injury concerns but changes are possible following the 4-0 hammering at Stamford Bridge. Billy Clarke (knee) is a long-term absentee.
Blackburn will be without the quartet of David Dunn, Keith Andrews, Vince Grella and Jason Roberts.
Grella sustained a hamstring problem in last weekend's draw against Fulham and did not feature in the Carling Cup defeat at Aston Villa in midweek. Dunn has not played since the end of August while Andrews and Roberts have yet to feature this season because of injury.
Manager Sam Allardyce will make changes to the side he named for the Carling Cup, with Paul Robinson returning in goal.
Blackpool (from): Gilks, Keinan, Eardley, Taylor-Fletcher, Crainey, Evatt, Adam, Vaughan, Varney, Ormerod, Campbell, Grandin, Harewood, Southern, Carney, Cathcart, Basham, Euell, Sylvestre, Demontagnac, Coid, Husband, Phillips, Edwards, Halstead.
Blackburn (from): Robinson, Nelsen, Samba, Salgado, Jones, Givet, Olsson, Nzonzi, Pedersen, Emerton, EH Diouf, MB Diouf, Kalinic, Benjani, Bunn, Chimbonda, Hoilett, Linganzi.