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Nikola Zigic dealt the fatal blow midway through the second half to sink the sorry Hammers.
The big striker nodded home from a Sebastian Larsson free-kick to seal the win and move Birmingham up to 16th.
Substitute Demba Ba rattled the woodwork on his debut but otherwise, the hosts rarely threatened the visitors' goal and Grant's position will now undoubtedly come under more scrutiny as a result.
Source: DSG