Both had been rested for the Cottagers' 1-1 draw with Wigan but Johnson (groin) and Murphy (knee) have failed to recover and Diomansy Kamara also misses out with an ankle injury.
Eye on the ball: Fulham will be without Murphy for the clash at St Andrew's
Simon Davies could make his first appearance for two months after recovering from a foot injury while all Roy Hodgson's international players, including the Republic of Ireland's Damien Duff and Stephen Kelly, are fit.
Team (from): Schwarzer, Zuberbuhler, Konchesky, Pantsil, Hangeland, Baird, Smalling, Kelly, Hughes, Etuhu, Dempsey, Gera, Andranik, Riise, Greening, Duff, Davies, E Johnson, Nevland, Seol, Zamora, Elm.
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Explore more:People:Stephen Kelly, Damien Duff, Danny Murphy, Andrew Johnson, Simon DaviesPlaces:Birmingham, Republic of Ireland