Ten-man Wales began their World Cup qualifying campaign with a 2-0 defeat as goals from Vincent Kompany and Jan Vertonghen gave Belgium victory in Cardiff.
Injury-hit Wales had made a solid start against the Group A favourites but their good work was undone when James Collins was shown a straight red for a reckless lunge on Guillaume Gillet after 25 minutes.
Manchester City skipper Kompany capitalised to give the visitors the lead with a header three minutes before the break, with Vertonghen sealing the three points with an unstoppable free-kick late on.
Wales had been heavy underdogs coming into the game, with Coleman not being helped by an injury list that included late withdrawal Joe Allen, Craig Bellamy, Wayne Hennessey, Neil Taylor, Andrew Crofts and Jack Collison.
But they made a good start, with a disciplined defensive display frustrating the classy visitors while also looking potent on the break. Wales fashioned the first real chance as Gareth Bale's cushioned header fell for David Edwards via a deflection off Vertonghen, but the Wolves man could only find the side-netting.
Bale carved out another chance after 18 minutes, ghosting past Dries Mertens, but his cross was too high for Simon Church. The hosts had a lucky escape at the other end as Collins brilliantly denied Thomas Vermaelen a point-blank header, before Mertens deflected effort rolled just wide of the far post.
But Welsh hopes crumbled when Collins, playing his first international since March 2011, saw red after his terrible challenge on Gillet. The West Ham defender and his team-mates seemed exasperated by the decision, although replays did not suggest he had any grounds for complaint.
Bale continued to pose Wales' best attacking threat and another purposeful surge from him came so close to finding the opener, but Church saw his shot blocked by Gillet. And the miss was punished when skipper Kompany got the better of Darcy Blake to head in at the near post from Mertens' pin-point corner to give Belgium the lead in the 42nd minute.
Belgium camped on the edge of the Wales box from the off at the start of the second half, with Axel Witsel blazing over and Mertens shooting straight at Boaz Myhill. Adam Matthews denied substitute Romelu Lukaku an easy finish with a fine defensive header, while Vertonghen hit the side-netting after linking wonderfully with Eden Hazard.
Belgium put the seal on the win in the 83rd minute when Wales captain Aaron Ramsey fouled Lukaku; Vertonghen stepped up to hammer the free-kick beyond Myhill and end home hopes of salvaging a point.