Bayern Munich defender Martin Demichelis will miss the first two months of the new Bundesliga season after damaging ankle ligaments.
The Argentina international suffered torn ligaments during training earlier in the week and is facing at least seven weeks on the sidelines.
New coach Louis van Gaal must now decide which youngster from Holger Badstuber and Breno should play alongside Daniel van Buyten during the opening weeks of the campaign.
"The length of this injury break is obviously bitter," said sporting director Christian Nerlinger.
"Martin has trained very intensely and played in the starting XI against Neckarelz.
"Let's just hope that the healing process goes perfectly and we can have him back as soon as possible."