Just one victory in 30 years and 13 visits for The Reds.
Defeat drops them back into the Championship relegation zone, and to second bottom, one point off safety.
Barnsley did manage to extend their scoring streak to a 16th consecutive league game thanks to Jacob Mellis’ 92nd minute consolation.
This 2-1 reverse gives Wednesday a league double over The Reds.
A player was sent off in this South Yorkshire derby for the first time in five meetings.
Martin Cranie (YC)
Marlon Harewood (YC)
Reuben Noble-Lazarus (for O’Brien 56)
Jason Scotland (for Dagnall 63)
Danny Rose (for Etuhu 78)
Ben Alnwick, Stephen Foster, Stephen Dawson, Tomasz Cywka.
Npower Championship results Saturday 30th March 2013:
Charlton 3-2 Bolton
Ipswich 3-0 Leeds
Nottingham Forest 2-2 Brighton
Peterborough 2-1 Cardiff
Sheffield Wednesday 2-1 BARNSLEY
Wolves 3-2 Middlesbrough
Huddersfield 0–1 Hull
Friday 29th March 2013:
Blackburn 1-1 Blackpool
Watford 3-3 Burnley
Crystal Palace 0-4 Birmingham
Derby 3-0 Bristol City
Leicester 0-1 Millwall
Barnsley lie in 23rd place in the Npower Championship with 44 points from 38 games.
We are 16 points off the Play-Offs 27 points off the Automatic Promotion Places, 31 points off First place and 1 point inside the Relegation Zone.
Up to 30.3.13
Npower Championship Matchday Thirty Nine: Barnsley v Leicester City Monday 1st April Kick-off: 3pm.
Adult, non-member: £23
Adult, member: £20
OAP, non-member: £16
OAP, member: £15
Students (18-20), non-member: £16
Students (18-20), member: £15
Juveniles (12-17), non-member: £16
Juveniles (12-17), member: £15
Juveniles (5-11): £5
On The Road:
Npower Championship Matchday Forty: Crystal Palace v Barnsley Saturday 6th April 2013: Kick-Off: 3pm
Juvenile Under 18: £15