The Reds have now conceded 17 goals in their last three trips to the blue half of Manchester and failed to extend their scoring run to a 16th match.
This is the second time in three visits that a City player has grabbed a hattrick.
After six straight victories under David Flitcroft The Reds have failed to win any of the last four, losing three
This is the third time they have been hit for five in 2012-2013.
In another blow, a victory for Bristol City and draw for Peterborough yesterday dropped Barnsley to the foot of the Championship table.
Ryan Tunnicliffe (YC)
Jacob Mellis (for Cywka 52)
Jason Scotland (for Dagnall 52)
Jim O'Brien (for Etuhu 52)
Lukas Lidakevicius, Bobby Hassell, Rory Delap, Danny Rose.
FA Cup Quarter-Final results Saturday 9th March 2013:
Everton 0-3 Wigan
Manchester City 5-0 Barnsley
Sunday 10th March 2013:
Millwall 0-0 Blackburn
Man United 2-2 Chelsea
Npower Championship results Saturday 9th March 2013:
Birmingham 3-1 Derby
Bolton 1-0 Brighton
Bristol City 1-0 Middlesbrough
Crystal Palace 2-2 Leeds
Huddersfield 0-1 Charlton
Leicester 0-1 Sheffield Wednesday
Nottingham Forest 3-1 Wolves
Peterborough 0-0 Ipswich
Watford 1-2 Blackpool
Barnsley lie in 24th place in the Npower Championship with 38 points from 35 games.
We are 19 points off the Play-Offs 28 points off the Automatic Promotion Places, 33 points off First place and 1 point inside the Relegation Zone.
Up to 10.3.13
Npower Championship Matchday Thirty Six: Barnsley v Brighton and Hove Albion Tuesday 12th March Kick-off: 7:45pm.
Adult, non-member: £23
Adult, member: £20
OAP, non-member: £16
OAP, member: £15
Students (18-20), non-member: £16
Students (18-20), member: £15
Juveniles (12-17), non-member: £16
Juveniles (12-17), member: £15
Juveniles (5-11): £5
On The Road:
Npower Championship Matchday Thirty Eight: Sheffield Wednesday v Barnsley Saturday 30th March 2013: Kick-Off: 3pm